Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber

Abstract Purpose Evaluation of a lozenge for targeted micronutrition (holo-BLG), new invention based on the farm effect, in house dust mite (HDM) allergic rhinoconjunctivitis (ARC) patients standardized allergen exposure chamber (AEC). Methods Eligible HDM were exposed to raw material an AEC 120 min before (V1) and after (V3) 3 months holo-BLG supplementation. Nasal, conjunctival, bronchial other symptoms rated by every 10 and, wellbeing, peak nasal inspiratory flow (PNIF), lung function parameters 30 min. Primary endpoint was change median Total Nasal Symptom Score (TNSS) at V3 compared V1 exposure. Secondary endpoints consisted exploratory analysis temporal evolution symptom scores using linear mixed effects models. Results A total 32 included analysis. significant improvement 60% ( p = 0.0034) primary TNSS (V1 2.5 [interquartile range, IQR 1–4], 1.0 [IQR 1–3]) observed. 40% seen 5.0 3–9], 3.0 2–4]; [Wilcoxon test: confidence interval 1.5–4.0, < 0.0003]). The all personal wellbeing revealed clinically meaningful over time, manifested lower increase during final No relevant differences observed PNIF parameters. Safety tolerability as excellent. Conclusions effect resulting immune resilience might help fight allergy epidemic front cells. Trial registration study retrospectively registered clinicaltrials.gov (NCT04477382).